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1

Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model

Paul Jennings, Christina Weiland, Alice Limonciel, Katarzyna M. Bloch, Robert Radford, Lydia Aschauer, Tara McMorrow, Anja Wilmes, Walter Pfaller, Hans J. Ahr, Craig Slattery, Edward A. Lock, Michael

Journal:

Archives of Toxicology

Year:

2012

Language:

english

File:

PDF, 282 KB

english, 2012

2

Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes

Alice Limonciel, Lydia Aschauer, Anja Wilmes, Sinikka Prajczer, Martin O. Leonard, Walter Pfaller, Paul Jennings

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 1.29 MB

english, 2011

3

Transcriptomic and functional alterations during renal epithelial maturation

Lydia Aschauer, Leonhard N. Gruber, Alice Limonciel, Martin O. Leonhard, Walter Pfaller, Anja Wilmes, Paul Jennings

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 87 KB

english, 2012

4

KBrO3 induces oxidative stress and tight junction alterations in proximal tubule cells

Alice Limonciel, Anja Wilmes, Lydia Aschauer, Robert Radford, Katarzyna Bloch, Craig Slattery, Edward Lock, Michael P. Ryan, Paul Jennings

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 90 KB

english, 2012

5

An overview of transcriptional regulation in response to toxicological insult

Paul Jennings, Alice Limonciel, Luca Felice, Martin O. Leonard

Journal:

Archives of Toxicology

Year:

2013

Language:

english

File:

PDF, 1.34 MB

english, 2013

6

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells

Alice Limonciel, Anja Wilmes, Lydia Aschauer, Robert Radford, Katarzyna M. Bloch, Tara McMorrow, Walter Pfaller, Joost H. van Delft, Craig Slattery, Michael P. Ryan, Edward A. Lock, Paul Jennings

Journal:

Archives of Toxicology

Year:

2012

Language:

english

File:

PDF, 2.14 MB

english, 2012

7

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

Wilmes, Anja, Limonciel, Alice, Aschauer, Lydia, Moenks, Konrad, Bielow, Chris, Leonard, Martin O., Hamon, Jeremy, Carpi, Donatella, Ruzek, Silke, Handler, Andreas, Schmal, Olga, Herrgen, Karin, Bellw

Journal:

Journal of Proteomics

Year:

2013

Language:

english

File:

PDF, 2.54 MB

english, 2013

8

Interleukin-19 as a translational indicator of renal injury

Jennings, Paul, Crean, Daniel, Aschauer, Lydia, Limonciel, Alice, Moenks, Konrad, Kern, Georg, Hewitt, Philip, Lhotta, Karl, Lukas, Arno, Wilmes, Anja, Leonard, Martin O.

Journal:

Archives of Toxicology

Year:

2015

Language:

english

File:

PDF, 872 KB

english, 2015

9

Application of a human renal proximal tubule cell line, RPTEC/TERT1, for chemical safety assessment

Aschauer, Lydia, Wilmes, Anja, Limonciel, Alice, Leonard, Martin O., Pfaller, Walter, Jennings, Paul

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 88 KB

english, 2014

10

Integration of transcriptomic, epigenomic, proteomic and metabolomic data for the characterisation of the molecular response of renal epithelial cells to repeat-dose exposure to chemicals in vitro

Limonciel, Alice, van Breda, Simone, Jiang, Xiaoqi, Tredwelll, Gregory D., Wilmes, Anja, Aschauer, Lydia, Theunissen, Daniel, Sachinidis, Agapios, de Kok, Theo, Keun, Hector C., Kopp-Schneider, Annett

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 72 KB

english, 2014

11

The use of transcriptomics to assess stress response pathway and nuclear receptor activation for uncovering mechanisms of chemical induced toxicity

Limonciel, Alice, Jennings, Paul

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 54 KB

english, 2014

12

Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics

Wilmes, Anja, Bielow, Chris, Ranninger, Christina, Bellwon, Patricia, Aschauer, Lydia, Limonciel, Alice, Chassaigne, Hubert, Kristl, Theresa, Aiche, Stephan, Huber, Christian G., Guillou, Claude, Hewi

Journal:

Toxicology in Vitro

Year:

2014

Language:

english

File:

PDF, 4.35 MB

english, 2014

13

Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study

Aschauer, Lydia, Limonciel, Alice, Wilmes, Anja, Stanzel, Sven, Kopp-Schneider, Annette, Hewitt, Philip, Lukas, Arno, Leonard, Martin O., Pfaller, Walter, Jennings, Paul

Journal:

Toxicology in Vitro

Year:

2014

Language:

english

File:

PDF, 2.18 MB

english, 2014

14

Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing

Crean, Daniel, Bellwon, Patricia, Aschauer, Lydia, Limonciel, Alice, Moenks, Konrad, Hewitt, Philip, Schmidt, Tobias, Herrgen, Karin, Dekant, Wolfgang, Lukas, Arno, Bois, Frederic, Wilmes, Anja, Jenni

Journal:

Toxicology in Vitro

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

15

Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation

Aschauer, L., Gruber, L. N., Pfaller, W., Limonciel, A., Athersuch, T. J., Cavill, R., Khan, A., Gstraunthaler, G., Grillari, J., Grillari, R., Hewitt, P., Leonard, M. O., Wilmes, A., Jennings, P.

Journal:

Molecular and Cellular Biology

Year:

2013

Language:

english

File:

PDF, 8.06 MB

english, 2013

16

Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing

Limonciel, Alice, Moenks, Konrad, Stanzel, Sven, Truisi, Germaine L., Parmentier, Céline, Aschauer, Lydia, Wilmes, Anja, Richert, Lysiane, Hewitt, Philip, Mueller, Stefan O., Lukas, Arno, Kopp-Schneid

Journal:

Toxicology in Vitro

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

17

A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity

Limonciel, Alice, Jennings, Paul

Journal:

Year:

2014

Language:

english

File:

PDF, 738 KB

english, 2014

18

Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline

Ranninger, Christina, Rurik, Marc, Limonciel, Alice, Ruzek, Silke, Reischl, Roland, Wilmes, Anja, Jennings, Paul, Hewitt, Philip, Dekant, Wolfgang, Kohlbacher, Oliver, Huber, Christian G.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 2.79 MB

english, 2015

19

Identification of novel mechanistic biomarkers of nephrotoxicity by proteomics and phosphoproteomics

Limonciel, A., Kollipara, L., Zahedi, R., Sickmann, A., Jennings, P.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 68 KB

english, 2015

20

Improving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry

Ranninger, Christina, Schmidt, Lukas E., Rurik, Marc, Limonciel, Alice, Jennings, Paul, Kohlbacher, Oliver, Huber, Christian G.

Journal:

Analytica Chimica Acta

Year:

2016

Language:

english

File:

PDF, 1.52 MB

english, 2016

21

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

Herwig, R., Gmuender, H., Corvi, R., Bloch, K. M., Brandenburg, A., Castell, J., Ceelen, L., Chesne, C., Doktorova, T. Y., Jennen, D., Jennings, P., Limonciel, A., Lock, E. A., McMorrow, T., Phrakonkh

Journal:

Archives of Toxicology

Year:

2016

Language:

english

File:

PDF, 2.00 MB

english, 2016

22

Differential effects of consecutive chemical exposure-recovery periods on the physiology and defence mechanisms of renal proximal tubule cells

Limonciel, A., Carta, G., Ringer, T., Van Breda, S.G., Kleinjans, J.C., Jennings, P.

Journal:

Toxicology Letters

Year:

2016

Language:

english

File:

PDF, 74 KB

english, 2016

23

Adverse outcome pathways: opportunities, limitations and open questions

Leist, Marcel, Ghallab, Ahmed, Graepel, Rabea, Marchan, Rosemarie, Hassan, Reham, Bennekou, Susanne Hougaard, Limonciel, Alice, Vinken, Mathieu, Schildknecht, Stefan, Waldmann, Tanja, Danen, Erik, van

Journal:

Archives of Toxicology

Year:

2017

Language:

english

File:

PDF, 2.60 MB

english, 2017

24

Quantification and relationship of stress and adversity in cellular systems

Limonciel, Alice

Journal:

Toxicology Letters

Year:

2017

Language:

english

File:

PDF, 82 KB

english, 2017

25

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

Limonciel, Alice, Ates, Gamze, Carta, Giada, Wilmes, Anja, Watzele, Manfred, Shepard, Peter J., VanSteenhouse, Harper C., Seligmann, Bruce, Yeakley, Joanne M., van de Water, Bob, Vinken, Mathieu, Jenn

Journal:

Archives of Toxicology

Year:

2018

Language:

english

File:

PDF, 3.38 MB

english, 2018

26

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

Zgheib, Elias, Limonciel, Alice, Jiang, Xiaoqi, Wilmes, Anja, Wink, Steven, van de Water, Bob, Kopp-Schneider, Annette, Bois, Frederic Y., Jennings, Paul

Journal:

Frontiers in Genetics

Year:

2018

Language:

english

File:

PDF, 5.24 MB

english, 2018

27

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Limonciel, Alice, van Breda, Simone G., Jiang, Xiaoqi, Tredwell, Gregory D., Wilmes, Anja, Aschauer, Lydia, Siskos, Alexandros P., Sachinidis, Agapios, Keun, Hector C., Kopp-Schneider, Annette, de Kok

Journal:

Frontiers in Genetics

Year:

2018

Language:

english

File:

PDF, 3.41 MB

english, 2018

28

Application of three approaches for quantitative AOP development to renal toxicity

Zgheib, Elias, Gao, Wang, Limonciel, Alice, Aladjov, Hristo, Yang, Huan, Tebby, Cleo, Gayraud, Ghislaine, Jennings, Paul, Sachana, Magdalini, Beltman, Joost B., Bois, Frederic Y.

Journal:

Computational Toxicology

Year:

2019

Language:

english

File:

PDF, 1.53 MB

english, 2019

29

Corrigendum: Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

Zgheib, Elias, Limonciel, Alice, Jiang, Xiaoqi, Wilmes, Anja, Wink, Steven, van de Water, Bob, Kopp-Schneider, Annette, Bois, Frederic Y., Jennings, Paul

Journal:

Frontiers in Genetics

Year:

2019

Language:

english

File:

PDF, 133 KB

english, 2019

30

Mid-gestation low-dose LPS administration results in female-specific excessive weight gain upon a western style diet in mouse offspring

Dijkstra, Dorieke J., Verkaik-Schakel, Rikst Nynke, Eskandar, Sharon, Limonciel, Alice, Stojanovska, Violeta, Scherjon, Sicco A., PlÃ¶sch, Torsten

Journal:

Scientific Reports

Year:

2020

File:

PDF, 1.34 MB

2020